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Navigating the Exome with DNAnexus

With a growing number of targeted exome capture solutions being integrated into the next-generation sequencing workflow, targeted exome analysis has become the go-to and cost-effective approach for obtaining sequence coverage of protein-coding regions of the genome. As a result, researchers are starting projects with larger populations, with larger, more complicated datasets. One reason targeted exome capture is gaining steam is because whole-genome sequencing is still cost prohibitive for most researchers.

To support this important methodology we have added Exome Analysis to our repertoire of analyses tools. With the DNAnexus Exome Analysis method, we’ve simplified a critical step in the processing and analysis of these datasets. Using this analysis you can quickly analyze exome sequence data by determining whether regions of interest have been sequenced with sufficient coverage to allow for further analyses.

For each exon, DNAnexus reports on the number and fraction of bases covered by sequence reads, along with the average coverage within the exon. Exons that are overlapping genes in a gene annotation track are labeled with the gene name to allow for easy follow-on searching for exons from a gene of interest.

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About DNAnexus

DNAnexus the leader in biomedical informatics and data management, has created the global network for genomics and other biomedical data, operating in 33 countries including North America, Europe, China, Australia, South America, and Africa. The secure, scalable, and collaborative DNAnexus Platform helps thousands of researchers across a spectrum of industries — biopharmaceutical, bioagricultural, sequencing services, clinical diagnostics, government, and research consortia — accelerate their genomics programs.

The DNAnexus team is made up of experts in computational biology and cloud computing who work with organizations to tackle some of the most exciting opportunities in human health, making it easier—and in many cases feasible—to work with genomic data. With DNAnexus, organizations can stay a step ahead in leveraging genomics to achieve their goals. The future of human health is in genomics. DNAnexus brings it all together.