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UK Biobank RAP Researcher Spotlight: August 2023

The Monthly Researcher Spotlight is our section highlighting the exciting work of the UK Biobank Research Analysis Platform user community. If you would like to be featured, email

This was simultaneously published in the August 2023 UK Biobank RAP Newsletter. You can sign up for future installments here.

This month's Spotlight features Mike Zhong, an engineer from TenSixteen Bio whose work focuses on creating workflows, apps, and other tools for bioinformatics pipelines.

1517372197298Mike Zhong
Principal Software Engineer
TenSixteen Bio


What are the focus and discovery highlights of your research?

TenSixteen Bio is focused on exploring the biology of Clonal Hematopoiesis of Indeterminate Potential (CHIP) and its role in various diseases. Our research has led to possibly the most comprehensive set of CHIP calls and the bioinformatics pipelines to make those calls.

What are some of the key questions that you are looking to answer using UKB data?

Using UKB data we connect somatic variants with germline genetics, phenotypic information, and clinical outcomes to understand the biology of clonal hematopoiesis to inform target and therapeutic discovery. By connecting these data in the large UKB cohort we’re able to answer questions about what factors predispose an individual to CHIP, how different types of CHIP progress to disease, and which targets are most amenable to therapeutic intervention. Working with the recently released proteomic data also lets us ask even more questions about the phenotypic impact of CHIP in a large cohort of individuals.

How has the UKB-RAP helped you perform your research?

UKB-RAP provides us with both the data and the computational environment to manipulate, explore, and interrogate the data required to test our hypothesis. The UKB technical support team is responsive and helpful in working hand-in-hand with our scientists to resolve any emergent issues and help us develop solutions that integrate with our own internal data and software systems.

Experience DNAnexus

Move Beyond Genomics

About DNAnexus

DNAnexus the leader in biomedical informatics and data management, has created the global network for genomics and other biomedical data, operating in 33 countries including North America, Europe, China, Australia, South America, and Africa. The secure, scalable, and collaborative DNAnexus Platform helps thousands of researchers across a spectrum of industries — biopharmaceutical, bioagricultural, sequencing services, clinical diagnostics, government, and research consortia — accelerate their genomics programs.

The DNAnexus team is made up of experts in computational biology and cloud computing who work with organizations to tackle some of the most exciting opportunities in human health, making it easier—and in many cases feasible—to work with genomic data. With DNAnexus, organizations can stay a step ahead in leveraging genomics to achieve their goals. The future of human health is in genomics. DNAnexus brings it all together.