Hello World! Come Take the new DNAnexus for a Test Drive

dnanexus betaToday marks the official beta launch of our new platform, and we can’t wait for you to try it out!

As our current users know, DNAnexus focuses on massively parallel, cloud-based solutions for analyzing, managing, and storing genomic data. With this beta launch of our new platform, we have a host of exciting new features and capabilities to tell you about.

The new DNAnexus has been developed with the expert analyst or bioinformatician in mind (our existing offering will now be known as DNAnexus Classic). The new DNAnexus is a secure and extensible genomics data analysis and collaboration environment designed to meet IT and compliance requirements, built for the bioinformatician in research or the clinic. If you are a bioinformatician who would like to dig into the technical side of genomics data analysis and you’re dealing with large amounts of sequence data, then this platform is for you. It is configurable, provides an ever-expanding genomics toolbox, and allows instant and secure data analysis and collaboration.

Here are a few highlights:

  1. Take advantage of a fully configurable and scriptable infrastructure through the command-line and documented APIs, SDK, and web browser.
  2. Leverage Amazon Web Services for scalable, cost-effective computing and data storage.
  3. Get started immediately by leveraging a genomics toolbox rich in industry-recognized analysis tools and datasets.
  4. Create your own custom analysis tools, filters, and workflows to run and distribute in the cloud.
  5. Visualize your genomic data via an integrated, HTML5-based genome browser.
  6. Securely share genomics data, analysis tools, and workflows.
  7. Take advantage of a system that has enterprise-grade security and has been designed for people in drug, device, or diagnostics development, as well as CLIA labs and clinical environments.
Of course, the best way to see what the new DNAnexus has to offer is by test driving it yourself. Today, we officially kick off the beta for the new DNAnexus. During this beta users may upload and analyze as much as 1 Tbyte of sequence data (which is more than enough to store and process one whole genome), create and tune workflows, check out the many available analysis tools and data sets, and much more. To sign up and create your free beta account, simply enter your email address here and we’ll contact you with details on how to get started.

Join DNAnexus for a Lunchtime Workshop at ASHG

Whether you join us for lunch to explore the dark matter of ENCODE or visit our booth (#507) to check out the latest updates and get a demo of DNAnexus, we’d love to catch up with you at ASHG. Plus, be entered to win an iPod Shuffle, when introducing yourself at the DNAnexus booth.

 

kundaje encodeWe are honored to have Dr. Anshul Kundaje, research scientist at MIT, review his latest ENCODE consortium paper and share insights into gene regulation. By looking at 119 transcription factors and regulatory proteins, Kundaje’s team found that chromatin diversity at the regulatory level is the norm, rather than the exception.

 

During this lunchtime talk you’ll discover how Kundaje and team used DNAnexus to process and map some 5 billion reads and identified chromatin patterns via a newly developed probabilistic mapping tool, the Clustered AGgregation Tool (CAGT). The clustering approach yielded dramatically different results compared to the standard method of averaging chromatin marks across populations. Importantly, Kundaje’s team was able to identify about 25 “metapatterns,” or signatures that represent the diversity of modifications across binding sites and cell types. These distinct patterns will be valuable for other scientists examining chromatin modifications and making inferences about what those changes are doing in the genome.

 

Details

• Wednesday, November 7th, 12:45 – 2:15 pm
• Moscone Center, Room 301 (Esplanade Level)
• Boxed lunch & refreshments will be provided!

 

Agenda

Introduction
Brigitte Ganter, Ph.D., Director of Product Marketing, DNAnexus

Ubiquitous Heterogeneity and Asymmetry of the Chromatin Environment at Human Regulatory Elements
Anshul Kundaje, Ph.D., Research Scientist MIT

DNAnexus: A Collaborative and Scalable Data Technology Platform
Andreas Sundquist, Ph.D., CEO and Co-founder, DNAnexus

 

Explore the data yourself; you’ll find the 20 samples accessible via DNAnexus in our Public Data folder, labeled Encode.

 

Relationships for Innovation

This week we announced new agreements with two premier healthcare institutions: Geisinger Health Systems (GHS) and the University of California, San Francisco (UCSF). We also announced, with Complete Genomics, our participation in its Genomics Discovery Partners program.

Each of these relationships opens exciting new opportunities. NGS technology generates terabytes of data requiring enormous storage capacities and supercomputing processing power to extract meaningful information. Academic research centers, university hospitals, and commercial organizations risk being overwhelmed by this rapidly growing amount of data. As researchers and clinicians seek to integrate these datasets into their work, industry leaders are increasingly investing to meet this data management analysis challenge.

We are excited to enable these industry leaders to innovate solutions with us on our cloud-based platform. GHS is integrating its genomic data assets with clinical applications, including parent-child trio studies for disease characterization and prevention. UCSF is uploading, managing, and analyzing sequencing data for large-scale genome sequencing research applications. Complete Genomics is offering our data management and visualization services to customers of their human genome sequencing service.

These relationships exemplify ways we help organizations to capitalize on opportunities created by the growing ubiquity of low-cost genomics data. Together we are applying these experiences to create new services and capabilities that support their customers, researchers, and clinicians.

Check back often for updates on these and other collaborations in the works.