Update to Ubuntu 14.04

Ubuntu 12.04 has reached end-of-life, and the DNAnexus team is taking  steps to ensure that customer applications and DNAnexus backend systems migrate away from this version of the software. We recommend any customers who develop and maintain DNAnexus applications update your applications and applets to Ubuntu 14.04 as soon as possible to identify any issues that may arise. We are currently using Canonical’s Extended Security Maintenance feature to help ensure the ongoing security and integrity of Ubuntu 12.04 systems, however, support for 12.04 DNAnexus applications and applets on all instance types will officially end on April 28th, 2018.

Tips for Updating to Ubuntu 14.04: 

  • If your application uses assets, ‘execDepends’, or installs from ‘apt’ directly within the application, it is recommended that you ensure any version changes in these packages when using Ubuntu 14.04 are compatible with your application. It may be helpful to use a Cloud Workstation to test out these differences.
  • Instead of using ‘execDepends’ for installing packages, consider using DNAnexus assets or Docker images. Your application will incur less runtime dependency on the network availability of Canonical packages, and by using Docker, you can choose different runtime environments, including Ubuntu 16.04, to encapsulate the core functionality of the application.

Beginning October 15th, 2017, the DNAnexus Platform will also require the ‘distribution’ and ‘release’ fields to be specified within the application’s ‘runSpec’ when building an applet. Please ensure that any applications you build from source contain those fields. Note that if you use ‘dx-app-wizard’ to generate an application template, these fields are populated for you. Please ensure you are using a recent version of the dx-toolkit when using ‘dx-app-wizard’ or performing a build. You can obtain the latest version of the toolkit from our wiki or by using the ‘dx upgrade‘ command.

Please do not hesitate to contact support@dnanexus.com with any questions or concerns regarding this software update.

DNAnexus and Saphetor Collaborate for Seamless Integration of Tertiary Analysis Solution

DNAnexus has teamed up with Saphetor, a leading variant analysis company, to build a sample-in, report-out genomic analysis solution. Saphetor annotates and classifies genetic variants from next-generation sequencing (NGS) data to help clinicians quickly and accurately diagnose disease to make faster, more precise treatment decisions. Saphetor’s technology is now available on the DNAnexus cloud-based platform.

Saphetor has built a powerful genome interpretation engine by integrating more than 30 public and licensed databases containing genotype, phenotype, variant, drug, and clinical trial information. Automated annotation ensures a comprehensive understanding of variant significance and implication for disease. Each variant is annotated with gene and functional position, protein functional impact, population allele frequencies, and pathogenicity prediction scores. Using the DNAnexus-Saphetor integration, researchers globally can conduct secure, whole-genome analysis leveraging Saphetor’s databases containing 33 billion variant annotation points.

Data from the DNAnexus Platform is exported to Saphetor via a secure API, enabling customers to take advantage of this comprehensive analysis solution. Saphetor’s powerful user interface allows customers to interactively browse and use powerful filters on the annotated and classified variant list in an intuitive fashion. Click on the image below to see a sample of the variant analysis interface.

Together with the scalability and high-performance computing power of the DNAnexus Platform, and Saphetor’s variant browsing tools, customers can quickly move from NGS data analysis to interpretation. Researchers can discover which variants have a functional impact on disease in the hopes of accelerating the implementation of precision medicine. We are excited about our collaboration with Saphetor to offer a secure and scalable environment to power an end-to-end analytical solution for genomic biomarker discovery and interpretation.

Interested in trying out Saphetor’s technology on DNAnexus? Get in touch with a member of our Science Team.

The New UI: Sleeker. Modern. Intuitive.

We are pleased to announce a design refresh of the DNAnexus web user interface! The new, modern interface incorporates visual enhancements that make the most common tasks and interactions intuitive and delightful, without changing the underlying functions that power your biomedical research. Explore some of the updates below, highlighted in yellow.

Project List

Your list of projects and files has a sleeker layout and more intuitive filtering system. Looking for your Bookmarks? The Bookmarks tab has been renamed to Saved Filters so you can quickly find and access the projects you’re looking for.

Project Page

Managing workflows has never been easier. The main actions are listed using clear, modernized icons to help you know exactly which steps to take next. Each file also has a context menu. Clicking on these three dots will help you accomplish actions such as view, copy, delete, and download one item at a time. You can still apply bulk action to all the files by clicking the icons at the top of the page.

App Library

The available apps are displayed in a simplified and visually appealing manner. The inputs and outputs of each tool are clearly shown, and finding the appropriate app for your analysis is now easier than ever. 

Billing Information

Your user settings have been reorganized to show your billing information in one distinct location. This will help you easily review your budget, spend, and remaining funds.

We hope these changes make using the DNAnexus web interface an intuitive and seamless experience. If you have any questions about the updates, let us know at support@dnanexus.com.