PMWC 2018: Leveraging Multi-Omic Datasets in Discovery & Clinical Trials

The Precision Medicine World Conference kicks off next week at the Computer History Museum in Mountain View, California. The program traverses innovative technologies, thriving initiatives, and clinical case studies that enable the translation of precision medicine into direct improvements.

Please join us for a lively panel discussion around scalable infrastructure/platforms that integrate next-generation sequencing (NGS) and other data (e.g. phenotypic) to power discovery in Pharma and the clinic.

Title: Scalable NGS Infrastructure/Platforms
Talk Details: Track 1 – Monday, January 22 at 10:30am
Moderator: Brady Davis, Chief Strategy Officer, DNAnexus

Panel Speakers:

  • AstraZeneca/MedImmune – David Fenstermacher, VP BioInformatics
  • Sutter Health – Greg Tranah,  Director, CPMC Research Institute, Adjunct Professor Dept. of Epidemiology & Biostatistics, UCSF
  • Carol Franc Buck Breast Cancer Center at UCSF– Laura Esserman, Director
  • City of Hope – Sorena Nadaf, SVP & CIO

Abstract:

Health care providers increasingly require multi-omic datasets, including phenotypic data informed by genomic data. Such data needs to be obtained in an economically sustainable way and made available on an agile user-friendly platform so that these data may inform clinical care and lead to health improvements.

Pharmaceutical companies (“Pharmas”) are interested in obtaining datasets containing phenotypic/clinical and genomic information generated from patient cohorts of specific disease areas. Such datasets can help Pharma researchers identify drug targets or find biomarkers, validate hypotheses related to the interaction of genomics with disease or with specific therapies, and identify candidate populations for future clinical trials. Payers are also interested in the outcomes related to new discoveries and therapies in order to reimburse for these treatments.

This session will focus on how both healthcare provider organizations, Pharmas and Payers are working toward solving these complex and challenging problems from a technical and business model perspective.

 

PAG 2018: A Focus on Genome Assembly

The DNAnexus team is headed to San Diego, January 13-17, for the largest gathering of Ag-Genomics scientists in the world! The International Plant & Animal Genome Conference brings together over 3,000 leading genomic scientists in plant and animal research to discuss recent advancements, ongoing projects, and future studies in the field. Learn more about PAG and register here.

Visit DNAnexus in booth #431 to learn how we can be your partner for complex genome assembly, structural variation analysis, and physical mapping to achieve complete and accurate views of all types of genomic variation. Join our activities listed below, or email us to schedule a member of our team at the conference.

Demo Hour with PacBio

Transforming De Novo Assembly
Tuesday, January 16th, 10:00am-10:30am
DNAnexus Booth #431

Stop by our booth to learn how to leverage PacBio’s FALCON and FALCON-Unzip tools on DNAnexus for streamlined genome assembly. Bioinformaticians from PacBio and DNAnexus will be available to answer questions.

DNAnexus Workshops

The Data Backbone for the Vertebrate Genome Consortia
Tuesday, January 16th, 1:30pm-3:40pm
Sunset – Meeting House

Brett Hannigan, PhD, Director of Scientific Partnership, will discuss how the Vertebrate Genomes Project at the Sanger Institute leverages DNAnexus to access approved tools, pipelines, and datasets generated by the consortia.

An Interactive Dot Plot Viewer for Comparative Genomics
Wednesday, January 17th, 11:45am-12:00pm
Digital Tools and Resources Program – California Room

Maria Nattestad, PhD, Scientific Visualization Lead, will debut Dot, our interactive dot plot viewer that enables scientists to visualize genome-genome alignments in order to evaluate new assemblies and perform explorative comparative genomics.

Dot will also be presented as a poster (PO104) Monday, January 15th from 10:00am-11:30am in the Grand Exhibit Hall.

At Bio-IT World: Promoting Technological Innovation to Advance Precision Medicine

We are excited to join the 3,000+ researchers, clinicians, and pharmaceutical and IT professionals attending the Bio-IT World Conference in Boston next week. The DNAnexus team will be onsite and headquartered in booth #316, please stop by to learn how DNAnexus helps improve secondary analysis, facilitates collaboration, and provides a scalable and secure platform for genomic research. Register here to attend the conference.

A highlight of the event every year is the Bio-IT World Best Practices Awards. This prestigious award highlights outstanding examples of how technological innovation can be powerful forces of change in the life sciences. This year, our partner M2Gen is a Best Practices Award finalist!

M2Gen has partnered with 15 of the nation’s leading cancer centers via the Oncology Research Information Exchange Network (ORIEN) to deliver informatics-based solutions to accelerate therapy discovery and development. The DNAnexus cloud platform supports molecular data access, management, collaboration, and analysis for ORIEN. This cloud-based approach creates value for all stakeholders, impacting the point-of-care and driving basic cancer research in both academic centers and industry. The multiple categories of the Best Practices Awards will be announced live during the plenary session on Thursday May 25th.

Dr. Hongyue Dai, PhD, CSO of M2Gen, will be in the DNAnexus booth to answer questions and showcase M2Gen’s innovative cancer data network. Come by booth 316 at 10:00am ET on Thursday to learn more.

We will also be showcasing projects with our clinical and software partners. See our full list of activities below. Can’t make it to one of our events? Stop by booth 316 anytime during the conference, or email us to schedule a meeting with a member of our team.

Scaling the World’s Fastest Clinical Genomic Pipeline for Critical Care in Pediatrics
Narayanan Veeraraghavan, PhD, Director of IT, Rady Children’s Institute for Genomic Medicine
Wednesday, May 24, 10:00am-10:30am
DNAnexus Booth #316

Genomic Solutions in Microsoft Azure
Singer Ma, Scientific Operations Director, DNAnexus

Wednesday, May 24th, 2:30pm-3:00pm

Microsoft Booth #529

Rapid Variant Discovery with Sentieon
Brendan Gallagher, Business Development, Sentieon
Wednesday May 24, 3:30pm – 4:00pm
DNAnexus Booth #316

Meet & Greet with M2Gen
Hongyue Dai, PhD, Chief Scientific Officer, M2Gen

Thursday May 25, 10:00am-10:30am

DNAnexus Booth #316